Biochemistry 4th edition

Biochemistry, 4th Edition. Christopher K. Anthony-Cahill, Western Washington University. If You're an Educator Download instructor resources Additional order info. Description The fourth edition of Biochemistry preserves the clear writing, strong physical chemistry background, and the use of the "Tools of Biochemistry" feature to underscore the experimental nature of biochemistry. This edition has been comprehensively and consistently updated to present the current developments in a rapidly evolving field.

Updated "Tools of Biochemistry" sections Keeps current with today's discoveries. Partial list of new or significantly revised topics includes: phosphorothioate bonds in DNA; the evolution of metabolic pathways; energy homeostasis; calorie restriction and lifespan extension; DNA methylation and epigenetics; chromatin remodelling and transcriptional control; RNA interference, noncoding RNAs, and riboswitches More life science applications throughout the text including biofuels, artificial phtosynthesis, and mapping disease genes Companion website with Pearson eText and animations Engaging questions for students that require analytical or quantitative thought Over new figures and pieces of art throughout the text.

New to This Edition. NEW - Co-authors. Organization and comprehensiveness of previous editions have been strengthened by the complementary strengths of three principle authors: Spencer J. Anthony-Cahill in structural and mechanistic biochemistry Dean R. Appling in metabolic biochemistry and mechanistic enzymology Christopher K. NEW - Keeping current with today's discoveries. Expanded presentation of mechanisms of enzyme-catalyzed reactions, while maintaining the indissoluble link between the biological and chemical sides of biochemistry.

Significant reorganization in the chapters dealing with intermediary metabolism and with genetic biochemistry. Partial list of new or significantly revised topics include: Phosphorothioate bonds in DNA; the evolution of metabolic pathways; energy homeostasis, calorie restriction and lifespan extension; DNA methylation and epigenetics; chromatin remodelling and transcriptional control; RNA interference, noncoding RNAs, and riboswitches. NEW - More life science applications.

The addition of more examples of practical application of biochemical knowledge integrated into the text, including: Influenza virus neuraminidase and the action of Tamiflu Chapter 9 Biofuels Chapter 13 Mitochondrial diseases Chapter 15 Artificial photosynthesis Chapter 16 Diabetes and obesity Chapter 18 Calorie restriction and lifespan extension Chapter 18 Methylenetetrahydrofolate reductase variants and disease susceptibility Chapter 21 Chromosomal translocations and targeted cancer drugs Chapter 23 Mapping disease genes Chapter 24 NEW - Companion website with Pearson eText and animations.

Wherever possible, we have removed problems that emphasize rote learning and retained or added problems that require analytical or quantitative thought to be solved. Several new problems have been added to each chapter. NEW - Remarkable artwork. Updating the text with over new figures and pieces of art. Share a link to All Resources.

Biochemistry is a field of enormous fascination and utility, arising, no doubt, from our own self-interest. Human welfare, particularly its medical and nutritional aspects, has been vastly improved by our rapidly growing understanding of biochemistry.

Indeed, scarcely a day passes without the report of a biomedical discovery that benefits a significant portion of humanity. Further advances in this rapidly expanding field of knowledge will no doubt lead to even more spectacular gains in our ability to understand nature and to control our destinies.

It is therefore essential that individuals embarking on a career in biomedical sciences be well versed in biochemistry. This textbook is a distillation of our experiences in teaching undergraduate and graduate students at the University of Pennsylvania and Swarthmore College and is intended to provide such students with a thorough grounding in biochemistry.

We assume that students who use this textbook have had the equivalent of one year of college chemistry and sufficient organic chemistry so that they are familiar with basic principles and nomenclature. We also assume that students have taken a one-year college course in general biology in which elementary biochemical concepts were discussed.

Students who lack these prerequisites are advised to consult the appropriate introductory textbooks in those subjects. Since the third edition of Biochemistry was published in , the field of biochemistry has continued its phenomenal and rapidly accelerating growth. This remarkable expansion of our knowledge, the work of many thousands of talented and dedicated scientists, has been characterized by numerous new paradigms, as well as an enormous enrichment of almost every aspect of the field.

For example, the number of known protein and nucleic acid structures as determined by X-ray and NMR techniques has increased by over 3-fold.